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"The main psychedelic component of magic mushrooms is psilocybin, which shows promise as a treatment for depression and other mental disorders. Psychedelic effects are believed to emerge through stimulation of serotonin 2A receptors (5-HT2ARs) by psilocybin’s active metabolite, psilocin." "Psilocybin is a psychedelic compound found in "magic mushrooms", often in the Psilocybe genus. It's used in spiritual rituals, recreationally, and as medicine."

"Psilocybin is a Schedule I substance under the Controlled Substances Act, meaning that it has a high potential for abuse, no currently accepted medical use in treatment in the United States, and a lack of accepted safety for use under medical supervision." "Mean scores (1: not at all harmful, 5: very harmful) of the perceived harm of the five substances according to 105 survey participants."

"September 27, 2022 - Psilocybin has become increasingly popular in pharmaceutical research to treat multiple neurological and mental health conditions. The FDA recently approved an investigational new drug (IND) application from Xpira Pharmaceuticals." "Understanding FDA Regulatory Requirements for Investigational New Drug Applications for Sponsor-Investigators."

"Psilocybin mushrooms lack the same addictive potential of more common drugs of abuse (e.g., opioids, stimulants)." "Given that more than 100,000 people died after overdosing on opioids and other drugs in the U.S. last year, it’s an understatement to say it’s urgent to find new, effective treatments for substance use disorder."


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