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US6630507B1 Grant 2003/10/07 Priority 1998/04/21
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.
Phytocannabinoids Beyond THC & CBD
A May 2019 molecular biology study assayed eleven cannabinoids in a pre-clinical Alzheimer’s disease platform for their ability to remove intra-neuronal amyloid and neuroprotection. Nine of the 11 were able to remove intra-neuronal Ab, reduce oxidative damage and protect neuronal function (4). The combination of 2 cannabinoids- THC and CBN- led to synergistic neuroprotection.
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Patent Protection for Cannabis?
"What is RSO? In 2003, Rick Simpson created a cannabis oil after three suspicious bumps on his arm turned out to be basal cell carcinoma, a form of skin cancer."
What is Rick Simpson Oil? | Make & use RSO | Leafly
"In the late 1990s, Simpson was removing asbestos from a poorly ventilated hospital boiler room when he collapsed from toxic fumes and knocked himself unconscious. Simpson was given immediate medical attention, however, he continued to suffer from dizziness and ringing in his ears (also known as tinnitus) for years following the incident."
"Some years later, in 2003, Simpson was diagnosed with a form of skin cancer known as basal cell carcinoma. This led him to further explore marijuana as medicine. Simpson read a study from The Journal of the National Cancer Institute in which Tetrahydrocannabinol or THC (the main psychoactive cannabinoid in marijuana) was found to kill cancer cells in mice."
"Making your own RSO at home is not difficult, and the process isn’t all that different from making cannabutter or other kinds of infused cannabis oil."
Rick Simpson Oil for Alzheimer's
“I think all we can say safely so far is using low doses of marijuana for prolonged periods of time at some point in your life, possibly when you’re middle-aged to late middle-aged, is probably going to slow the onset or development of dementia, to the point where you’ll most likely die of old age before you get Alzheimer’s." These were the words of Dr. Gary Wenk,Professor of Psychology & Neuroscience & Molecular Virology, Immunology and Medical Genetics at the Ohio State University and Medical Center."
"National Library of Medicine National Institutes of Health, that cannabinoids can act as a guard against any neuro-toxicities that might contribute to the disease. Amyloid plaque, which we’ve established earlier while talking about Alzheimer’s, that marijuana reduces, is a toxic protein accumulation which stops cells from proper communication between them. It is this plaque that over time causes the developing of the saddening Parkinson’s disease."
"Neurogenesis is the process by which brain cells grow, specifically in the hippocampus section, which is the part of our brain responsible for emotion and memory, as well as the primary producer of neurons. In a 2005 study, Dr. Xia Zhang at the University of Saskatchewan in Canada confirmed that cannabinoids can cause neurogenesis. “Most ‘drugs of abuse’ suppress neurogenesis," remarked Dr. Zhang. “Only marijuana promotes neurogenesis". Not only does this process revitalize a person’s brain, but the slowdown of it can cause severe mood disorders, such as depression, anxiety, and stress, all of which are related to a lack of sufficient rates of neurogenesis. The process of neurogenesis is usually slowed down due to stress and aging. That is the reason why marijuana is one of the most effective remedies to such mood disorders, and also a strong anti-aging therapeutic substance."
"Despite what we have heard all our lives about how hazardous marijuana was to our brains, the evidence that has been emerging for the past decade strongly supports the use of marijuana or cannabis oil (Rick Simpson oil) as a catalyst to brain cell growth and a deterrent to fatal brain diseases and disorders."
What are cannabis and marijuana?
"A. Cannabis is a plant of the Cannabaceae family and contains more than eighty biologically active chemical compounds. The most commonly known compounds are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Parts of the Cannabis sativa plant have been controlled under the Controlled Substances Act (CSA) since 1970 under the drug class "Marihuana" (commonly referred to as "marijuana") [21 U.S.C. 802(16)]. "Marihuana" is listed in Schedule I of the CSA due to its high potential for abuse, which is attributable in large part to the psychoactive effects of THC, and the absence of a currently accepted medical use of the plant in the United States."
117th Congress (2021-2022): MORE Act of 2021
What is the MORE Act?
"The MORE Act — the Marijuana Opportunity, Reinvestment and Expungement Act — is historic in scope. It would end the criminalization of cannabis for adults by removing it from the list of controlled substances, eliminate related criminal penalties, and take several other major steps toward criminal justice reform, social justice, and economic development."
Chairman Nadler Statement for the Markup of H.R. 3617, the MORE Act of 2021
"Serious criminal justice reform cannot begin in our country without ending the war on cannabis. The MORE Act would remove cannabis from the Controlled Substances Act, striking at the core of its harmful status in federal law, and it would provide essential restorative justice provisions to begin to undo decades of harm caused by prohibition"